differential immunohistochemical expression pattern of galectin-3 in normal and osteoarthritic human articular cartilage

نویسندگان

mahmoud orazizadeh

department of histology, medical school, ahwaz jondishapour university of medical sciences (ajums), ahwaz, iran donald m salter

department of pathology, medical school, edinburgh university, edinburgh, scotland, uk

چکیده

background: previous studies have shown that galectin-3, a member of lectin family, is expressed in developing cartilage in mouse embryo and also in growth plate of long bones.   objective: in the present work, the expression pattern of galectin-3 in normal and various grades of osteoarthritic (oa) human articular cartilage has been studied.   methods: using immunohistochemistry and standard western blotting, the in vivo and in vitro expression pattern of galectin-3 in normal and oa human articular cartilage were assessed.   results: immunohistochemical studies showed a similar pattern of galectin-3 expression in normal and mild oa but severe oa showed different strong expression in all zones of human articular cartilage.   conclusion: increased expression pattern of galectin-3 in advanced stages of oa may occur as a result of the imbalance of chondrocyte homeostasis that occurs in oa cartilage and provides a condition to modify normal chondrocyte to an oa chondroctye.

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Differential Immunohistochemical Expression Pattern of Galectin-3 in Normal and Osteoarthritic Human Articular Cartilage

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عنوان ژورنال:
iranian journal of immunology

جلد ۲، شماره ۲، صفحات ۷۸-۸۶

کلمات کلیدی
[ ' a r t i c u l a r c a r t i l a g e ' , ' g a l e c t i n ' , 3 , ' o s t e o a r t h r i t i s ' ]

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